As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden.Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture, mosaicpl
Abstract Background Oropharyngeal dysphagia or swallowing difficulties are common in acute care and critical care, affecting 47% of hospitalised frail elderly, 50% of acute stroke patients and approximately 62% of critically ill patients who have been intubated and mechanically ventilated for prolonged periods.Complications of dysphagia include asp
Abstract Background Degummed silk fibroin from Bombyx mori (silkworm) has potential copyright capabilities for drug delivery in humans; however, the processing methods have yet to be comparatively analyzed to determine the differential effects on the Grill Rack silk protein properties, including crystalline structure and activity. Methods In this s
Abstract Background There is variation in cardiac catheterization utilization across jurisdictions.Previous work from Alberta, copyright, showed no evidence of a plateau in the yield of high-risk disease at cardiac catheterization rates as high as 600 per 100,000 population suggesting that the optimal rate is higher.This work aims 1) To determine i
Planning for a bus-based regional evacuation is essential for emergency preparedness, especially for hurricane or flood prone urban environments with large numbers of transit-dependent or transit-captive populations.This paper develops an optimization-based decision-support model for pedestrian–bus evacuation planning under bus fleet, pedestrian